Due to how the upgrade system works, DMC3 is best on your first playthrough, if you commit to one play style for most/all of the game.
The skill ceiling in the game is fairly high, because the enemies are designed well and also placed well, in relation to the environments.
Actually using your skill and tools is pretty easy, as the way the combat controls is very good. and you will find uses for all of the weapons. Its not a game where I favored 1 or 2 weapons, the entire time.
Play DMC3 with Swordmaster style, if you want to really uncover the true depth of the combat.