Not a game recommendation here, but a very useful tool for filtering when browsing itch. On any browse query, append this to the URL:
?exclude=tg.horror
e.g.,
https://itch.io/games?exclude=tg.horror
Substitute “horror” with your tag of choice (horror being the example because I’ve become very exhausted by seeing 1,000 haunted VHS PlayStation lo-fi aesthetic retro 90s horror games—using this surfaced some stuff that’s very much my shit from the main browser pages, which rarely happens otherwise; no shade if that’s your jam, but it really ain’t mine). Unfortunately, it doesn’t seem like excluding multiple tags at once is possible.